George M. Rodgers's ADAMTS13: Biology and Disease PDF

By George M. Rodgers

ISBN-10: 3319087169

ISBN-13: 9783319087160

ISBN-10: 3319347306

ISBN-13: 9783319347301

This finished quantity discusses the protease ADAMTS13, summarizing the present prestige of easy and scientific study. The 9 authoritative chapters start with a old standpoint by means of exploration of the biochemistry and structure-function relationships of ADAMTS13 in addition to its common functionality in hemostasis (cleavage of von Willebrand factor). rising study issues for ADAMTS13 are lined, together with its power position in angiogenesis and different facets of mobile biology. extra subject matters comprise laboratory assays for ADAMTS13, inherited ADAMTS13 deficiency, and bought ADAMTS13 deficiency. A bankruptcy on comparable thrombotic microangiopathic (TMA) problems examines the variations among TMAs linked to ADAMTS13 deficiency and people no longer linked to ADAMTS13 deficiency. a last bankruptcy stories the initial details on rising facets of ADAMTS13, reminiscent of the prestige of recombinant ADAMTS13 items and their capability utility.


Comprehensive in its exploration of the ADAMTS13 protease in disease, ADAMTS13: Biology and disorder is an important source for medical hematologists, transfusion drugs physicians, and researchers attracted to hemostasis, vascular biology, biochemistry, and metalloproteases.

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ADAMTS13: Biology and Disease by George M. Rodgers

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